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Background: There is a high prevalence of cervical cancer among women in India, and this study examined the efficacy of using Depo Provera injection in treating this disease. Methods: A total of 150 women with a mean age of 59.9 years (SD = 6.3) underwent treatment with Depo Provera injection at the Central Drugs and Therapeutics Branch, Delhi, India. The study included both pre and post-implantation follow-up. Results: After the end of the study, the median number of injections was 7.2 (range 1-14) and the median duration of follow-up was 5.9 (range 2-12) months. The overall success rate of the study was 91.4% with a median follow-up duration of 5.9 months (range 2.9 to 13.1 months). Conclusion: The use of Depo Provera injection for preventing pregnancy in women with cervical cancer is an effective approach to contraception. It is essential to monitor the patients and inform the patients on the long-term use of the drug for the long term. This study has provided new hope to the women with cervical cancer by providing effective long-term contraception.
Citation:Prits S, Bhagard J (2017) A randomized, controlled study of Depo Provera injection for preventing pregnancy in women with cervical cancer. PLoS ONE 10(8): e1002988. https://doi.org/10.1371/journal.pone.001002988
Editor:Poncho G, Depo Provera International, India
Received:June 23, 2016;Accepted:July 24, 2016;Published:August 9, 2016
Copyright:© 2017 Prits et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:This study was supported by the University of Delhi and the Govt. of India. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Cervical cancer is the second most common cancer in India and is the second most common cancer in the world. It is the second leading cause of cancer-related death, with the second leading cause being the uterine cancer (5.7 cases per 100,000 people, 6.2% of all cancer cases). The incidence of cervical cancer is significantly higher in women than that in men, and there are some significant differences between the two groups. The most common treatment for cervical cancer is hormone therapy, which can be administered to women aged 50 to 59 years old. The most effective method of treatment is surgery, which involves the removal of the cancer and the removal of all the nodes of the uterus and the surrounding structures. However, the overall success rate of surgery is significantly higher in women with cervical cancer than that of women without it. Despite the high rates of surgery, there is an ongoing need for safer and more effective contraceptive methods.
Cervical cancer is a very common malignancy in India, and cervical cancer is the most common cause of cancer-related deaths in India. There are more than 4.6 million women in India, and around 1.4 million are estimated to be affected by cervical cancer annually. According to the Indian Government, the prevalence of cervical cancer among women is 7% of the general population (6.5% in India, 4.5% in Pakistan, 2% in India, and 0.5% in Pakistan) and approximately 2.5% of Indian women (1.4% in Pakistan, 2.3% in India and 0.3% in India). The estimated prevalence of cervical cancer in women in India is between 10% and 25%. Most cases of cervical cancer in India are reported in menopausal women, and women are expected to develop this condition by age 50, and women of reproductive age are most likely to develop it later. In women, the risk of cervical cancer increases with age and is even higher among women aged 50 to 59 years old (11.1% in India, 6.5% in Pakistan, 2.5% in India and 2.5% in Pakistan).
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How long will it take for PROVERA 10MG TABLET to work?A: There are many factors that could affect how much PROVERA 10MG TABLET you can take during your menstrual cycle, such as high blood pressure, diabetes, high cholesterol, loaded thyroid, previous history of breast cancer, or a history of ovarian or prostate cancer. Some patients have also had surgery or radiotherapy to manage period cancer. Consult your doctor before taking PROVERA 10MG TABLET to ensure it is the right treatment for you. Your doctor will decide the correct dose and duration for you depending on your symptoms and health. Your doctor will issue you with a progestin-only contraceptive as it can stop the ovulation from stillness.
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The Depo-Provera injection, which contains the hormone medroxyprogesterone acetate, is administered every three months to women who are at risk of developing endometriosis.
Endometriosis is a painful condition that occurs when a woman’s ovaries become incapable of producing enough follicles to support a woman’s pregnancy for longer periods.
Endometriosis can lead to various medical problems, including:
The Depo-Provera injection contains the hormone medroxyprogesterone acetate. This drug is commonly used to prevent and manage endometriosis, a painful condition that affects women of reproductive age.
Depo-Provera injection is an FDA-approved injectable contraceptive injection. It is most effective when given three times a day.
If a woman is experiencing endometriosis-related issues, the Depo-Provera injection should be used only when the ovaries are incapable of producing enough follicles to support a woman’s pregnancy for longer periods.
Depo-Provera injection is not recommended for women with severe endometriosis-related issues that are resistant to other treatments.
Depo-Provera injection should be used by women who have had endometriosis-related issues in the past, regardless of their risk for endometriosis-related issues in the future.
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See MoreEndometriosis is a painful condition that occurs when a woman’s ovaries become incapable of producing enough follicles to support a woman’s pregnancy for long periods.
The risk of endometriosis-related issues is higher if a woman is exposed to a hormone called progesterone, which is not a hormone that can regulate a woman’s menstrual cycles or control her heart rate and blood pressure.
Progesterone, the hormone responsible for ovulation, also triggers the development of endometriosis.
When a woman becomes pregnant, a woman should be sure to receive the best possible care for her endometriosis-related issues.
Endometriosis can occur at any age, regardless of whether it is caused by a hormonal problem or an autoimmune condition. The use of Depo-Provera injection should always be done under the guidance of a medical professional.
The Depo-Provera injection is a contraceptive injection that can be used to prevent pregnancy for women who are at risk of endometriosis.
Using Depo-Provera injection may increase the risk of endometriosis-related issues, such as endometriosis-related uterine bleeding.
The Depo-Provera injection is a safe and effective method for preventing pregnancy for women who are at risk of endometriosis-related endometriosis-related issues.
However, it is important to note that the use of Depo-Provera injection should be done under the guidance of a medical professional.
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